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By Frank J. Dixon

"The sequence which all immunologists need." --The Pharmaceutical magazine "Advances in Immunology needs to locate itself one of the so much energetic volumes within the libraries of our universities and institutions." --Science "Deserves an everlasting position in biomedical libraries as an reduction in examine and in instructing" --Journal of Immunological equipment "A provocative and scholarly evaluation of analysis" --Journal of the yank clinical organization "Provides a very worthy resource of reference and lots of stimulating ideas...the major repository of knowledge in a swiftly devloping topic" --The Lancet "Provides unrivalled worth in either educational and financial phrases and may be bought through difficult pressed librarians as a huge precedence to be jealously defended." --Journal of scientific Microbiology "A very beneficial serial critical scholar of immunology can have the funds for to be with no it." --Archives of Biochemistry and Biophysics Key positive aspects * concentrate on parts of the V(D)J recombination equipment that would be with regards to illnesses in people and animals * keep watch over of the supplement procedure by way of keep watch over of C3/C5 convertase on host cells, regulate of fluid part C3/C5 convertases, keep an eye on of fluid section MAC, and keep an eye on of deposited MAC * Immunodeficiency as a result of an entire absence of MHC category II expression and trans-acting components controlling transcription * present wisdom of IL-2R signaling, highlighting IL-2 signaling, and T-cell development rules * practical function of CD40 in cells, the in vivo value of CD40-CD40-L interactions, and the sign transduction equipment activated following crosslinking of the CD40 antigen * Integrative method of larger comprehend the saw heterogeneity of someone reaction to allergens * rules of isotype specificity, change recombination rules, and the mechanism of switching * lymphocyte-specific proteins, RAG1 and RAG2, start up V(D)J recombination of antigen receptor genes

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As the CD40 cytoplasmic segment does not contain any enzymatic domain, it is likely that the CD4O-mediated protein tyrosine kinase activity occurs through activation of separate kinases. This way of coupling cell surface receptors to intracellular signaling pathways seems to be a general concept which is also used by most cytokine receptors (Taniguchi, 1995). , 1989). Therefore, most results on signal transduction cannot be extrapolated to all B cells, and might explain the sometimes controversial data.

Therefore, most results on signal transduction cannot be extrapolated to all B cells, and might explain the sometimes controversial data. , 1991). Activation of protein tyrosine kinases (PTK) appears important for the transduction of CD40 signals because E'TK inhibitors inhibit B cell aggregation (Kansas and Tedder, 1991) as well as CD40-mediated rescue of germinal center B cells (Knox and Gordon, 1993). , 1994). , 1994). This latter study also suggests that atklbtk might be involved in CD40 signaling, since atk/btkdeficient EBV-transformed B cells derived from XLA patients display altered CD40 responses.

A similar inhibitory effect of CD40 engagement could be demonstrated in vivo in SCID mice bearing these tumor cell lines. The alteration in signal transduction that results in such a negative signal remains to be identified. , 1992). 3. Reed Sternberg Cells Reed Sternberg cells, characteristic of Hodgkin's lymphomas, can bind to CD40-L-expressing cells. , 1995). , 1994). 4. Hemutopoietic Progenitors CD40 activation of CD34' progenitors, isolated either from bone marrow or from cord blood, results in enhanced proliferation as shown by increased [3H]thymidine incorporation and viable cell numbers ( Flores-Romo, submitted for publication).

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